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Bubbles in Pericardial Fluid: Multimodality Imaging in Iatrogenic Hydropneumopericardium


1 Cardiovascular Medicine Department, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Students’ Research Committee, Shiraz University of Medical Sciences, Shiraz, IR Iran
*Corresponding author: Ali Reza Moaref, Cardiovascular Medicine Department, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel: +98-9173156216, Fax: +98-7116125601, E-mail: moarefa@sums.ac.ir.
Archives of Cardiovascular Imaging. 2015 February; 3(1): e22787 , DOI: 10.5812/acvi.22787
Article Type: Case Report; Received: Aug 14, 2014; Revised: Oct 26, 2014; Accepted: Oct 26, 2014; epub: Feb 20, 2015; ppub: Feb 2015

Abstract


Introduction: The term hydropneumopericardium describes the simultaneous accumulation of fluid and gas in the pericardial sac. This condition is mostly caused by primary infiltrative lesions from the adjacent organs, pericardial infections, or trauma and is a very rare situation, usually with favorable outcomes.

Case Presentation: We describe a female patient with Lutembacher’s syndrome complicated by cardiac tamponade. After surgical treatment, she developed iatrogenic hydropneumopericardium, which was treated conservatively.

Conclusions: Iatrogenic hydropneumopericardium can be managed conservatively with supportive measures, and most of these cases resolve spontaneously if they are not large and destabilizing.

Keywords: Pericardial Effusion; Pneumopericardium; Lutembacher's Syndrome

1. Introduction


Simultaneous accumulation of serous fluid and gas in the pericardial sac is called hydropneumopericardium. This very uncommon condition in adults (1) is mostly a consequence of primary infiltrative lesions from the adjacent organs, pericardial infections, or trauma (2) and usually harbors favorable outcomes. Still, the condition may become severe occasionally (1). Previously, most cases in adults were derived from gas-forming bacterial infections, also known as "pyopneumopericardium". With the advent of wide-spectrum antibiotics, however, this condition has become rare and other unusual causes such as paraesophageal hernia and surgical complications have become more prevalent (2). Here, we report a case of iatrogenic hydropneumopericardium in a patient with Lutembacher’s syndrome presenting with cardiac tamponade.

2. Case Presentation


A 55-year-old-woman, a known case of rheumatic mitral valve stenosis and congenital atrial septal defect (Lutembacher’s syndrome), referred to the emergency department complaining of dyspnea at rest. On primary evaluation, she had a blood pressure of 110/70 mmHg with a 15-mmHg paradoxical pulse. The jugular venous pressure was higher than 12 mm of H2O, and lung examination revealed pulmonary rales up to 2/3 of the lung. She was on Digoxin and Propranolol. Her electrocardiogram showed an atrial fibrillation rhythm with a controlled rate (90 beats per minute) alongside signs of right ventricular (RV) hypertrophy, which could be indicative of pulmonary hypertension (Figure 1). Primary echocardiogram showed the presence of rheumatic mitral valve stenosis (Figure 2A), accompanied by a large atrial septal defect (Figure 2B), leading to severe pulmonary hypertension (estimated systolic pulmonary arterial pressure = 100 mmHg) and enlarged dysfunctional RV and right atrium (RA) (Figure 2C), while the left ventricular (LV) function was preserved (ejection fraction = 55%). Also, a massive amount of pericardial effusion was noticed. As the presence of cardiac tamponade was suspected, the patient was sent for the surgical drainage of the pericardial fluid. After the removal of the drainage tubes, follow-up echocardiography revealed the presence of moderate amounts of fluid with a turbulent flow of air bubbles within the fluid (Figure 2D). A new chest radiograph, in comparison with the previous one, showed the appearance of an air-fluid level within the pericardial sac (Figure 3A, 3B). This finding, together with noticeable air bubbles, was also observed in the films from cardiac computed tomography (Figure 4A, 4B). The patient did not complain of dyspnea exacerbation after developing this problem, and the clinical signs of tamponade were absent. The acquired hydropneumopericardium was treated conservatively. A week later, no air was noticed in the pericardial sac on the follow-up echocardiogram.

Figure 1.
Electrocardiogram of the Patient, Showing an Atrial Fibrillation Rhythm with a Controlled Rate (90 Beats per Minute) alongside Signs of Right Ventricular Hypertrophy and Pulmonary Hypertension (Right Axis Deviation with qR Pattern in Lead V1, Secondary ST-T Change, and Deep S Waves in Leads V5 and V6)
Figure 2.
Findings of the Echocardiographic Examination of the Patient
Figure 3.
Radiologic Findings of the Patient
Figure 4.
Computed Tomographic Findings of the Patient

3. Discussion


Hydropneumopericardium is a very rare condition with a much lower frequency than pneumopericardium or pericardial effusion. Reported causes for this condition are as follows:

1) Most cases of hydropneumopericardium in the past were due to the involvement of the pericardium by gas-forming infectious agents, a process also called "pyopneumopericardium". With the advent of broad-spectrum antibiotics, however, other situations now constitute the more prevalent causes of this disease.

2) Currently, most cases are iatrogenic and secondary to the treatment of pericardial effusion via surgical or catheter-based fluid drainage approaches (1, 3).

3) Open or closed chest wall traumas can lead to the entrance of air into an inflamed pericardium (4).

4) Pneumomediastinum can progress secondary to alveolar rupture as a consequence of increased alveolar pressure (asthma, mechanical ventilation, cocaine inhalation, cough, or intense exercise) into the pericardial sac (5).

5) Drainage may occur from the adjacent hollow viscous organs such as the esophagus, stomach, and bronchial tree secondary to perforation and fistula formation as a complication of neoplasms, peptic ulcer, or even paraesophageal hernia (6).

6) rarely hydatid cysts can infect pericardium (7).

7) Idiopathic conditions have also been reported (2).

In 1931, Shackelford proposed the following criteria for the diagnosis of hydropneumopericardium: A) high-pitched tympanic percussion sound; B) loud metallic splashing sound synchronous with heart sounds; and C) characteristic chest X-ray with an air-fluid level in the pericardial cavity (4). Computed tomographic scan is also a useful tool as a guide to both diagnosis and determination of the etiology. Echocardiography may be able to show the presence of air-fluid interface in the pericardial sac (2); and as was the case in our patient, the presence of air bubbles within the pericardial fluid may also be deemed an echocardiographic sign for the detection of hydropneumopericardium. The course of the disease varies depending on the etiologic cause. Whereas most cases of pyopneumopericardium may experience a malignant and toxic course, the majority of the cases with iatrogenic hydropneumopericardium in the absence of a large and destabilizing hydropneumopericardium tend to resolve spontaneously with supportive measures (2), similar to our case.

Acknowledgments

The authors would like to thank Dr. Nasrin Shokrpour at the Center for the Development of Clinical Research of Nemazee Hospital for editorial assistance.

Footnotes

Authors’ Contributions: Armin Attar: Substantial contributions to conception and design, data acquisition, analysis, and interpretation, article drafting, critical revision of the article for important intellectual content, and final approval of the version for publication. Mohammad-Bagher Sharifkazemi: data acquisition, analysis, and interpretation, study supervision, critical revision for important intellectual content, and final approval of the version for publication. Alireza Moaref: data acquisition, analysis, and interpretation, study supervision, critical revision for important intellectual content, and final approval of the version for publication.

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Figure 1.

Electrocardiogram of the Patient, Showing an Atrial Fibrillation Rhythm with a Controlled Rate (90 Beats per Minute) alongside Signs of Right Ventricular Hypertrophy and Pulmonary Hypertension (Right Axis Deviation with qR Pattern in Lead V1, Secondary ST-T Change, and Deep S Waves in Leads V5 and V6)

Figure 2.

Findings of the Echocardiographic Examination of the Patient
A) Parasternal long-axis view clearly demonstrated severe rheumatic stenosis of the mitral valve (arrow) with a D-shaped interventricular septum, an enlarged RV, and a moderate amount of pericardial fluid. B) Color Doppler examination in the apical four-chamber view illustrated a large atrial septal defect (arrow) with a left-to-right shunt. C) The apical four-chamber view revealed normal-sized LV, RV enlargement and hypertrophy, and presence of severe biatrial enlargement. D) Parasternal short-axis view at the mitral valve level showed the presence of moderate amounts of pericardial effusion with turbulent bubbles inside (arrow), as well as RV dilatation. (Abbreviations: LA = Left Atrium, LV = Left Ventricle, PE = Pericardial Effusion, RA = Right Atrium, RV = Right Ventricle)

Figure 3.

Radiologic Findings of the Patient
A) Baseline chest X-ray examination showed severe cardiomegaly with prominent right descending pulmonary artery and interstitial pulmonary edema. B) The new chest radiograph demonstrated the appearance of an air-fluid level annotated by an arrow within the pericardial sac with improvement in the pulmonary edema.

Figure 4.

Computed Tomographic Findings of the Patient
A) An air-fluid level was visible in the films from cardiac computed tomography, and there was considerable dilation of the RA. B) There were evident air bubbles (marked by an arrow) in the lower zone of the pericardial sac. (Abbreviations: LV = Left Ventricle, RA = Right Atrium, RV = Right Ventricle)